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Hongye Forum No. 15
The first major finding from his lab was that an Arabidopsis gene could dramatically accelerate flowering of trees; this established a proof of concept for Arabidopsis genetics as a platform for biotechnological discoveries. His group later discovered the first plant microRNA mutant and identified the factor now known to be the long sought-after mobile flower-inducing signal. Detlef was one of the first to exploit natural genetic variation for understanding how the environment affects plant development, and he pioneered the application of next-generation sequencing technologies for describing and understanding genomic variation, including from herbarium samples. Today, this work incorporates questions at the interface of evolution and ecology: How can wild plants adapt to climate change, and how do they manage to keep their pathogens at bay? To support this work, he and his collaborators initiated over a decade ago the ‘1001 Genomes Project’ for Arabidopsis.
Detlef has served on many editorial and advisory boards, including HHMI’s Medical Advisory Board. He is a forceful advocate of open access publishing and helped to found the transformational journal eLife. He is also a co-founder of three biotech startups.
